产品货号：
Z17185
中文名称：
GPVI/GP6抗体
英文名称：
Anti-GPVI/GP6 Antibody
产品规格：
0.1mg
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-GPVI/GP6 Antibody |
| 指标别名 | GPIV;GPVI;BDPLT11;Platelet glycoprotein VI;Glycoprotein 6 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | ELISA,WB,IHC,IF |
| 基因名称 | GP6 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | GPVI antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of isoform 2 of the human GPVI.The immunogen is located within the last 50 amino acids of GPVI. |
| 计算分子量 | 37kDa |
| 成分 | GPVI Antibody is supplied in PBS containing 0.02% sodium azide. |
| 纯化方式 | GPVI Antibody is affinity chromatography purified via peptide column. |
| 浓度 | 1mg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 4℃可保存3个月，-20℃可保存1年。 |
| 背景资料 | Glycoprotein VI (GP6) is a 58kD platelet membrane glycoprotein that plays a crucial role in the collagen-induced activation and aggregation of platelets.It is uniquely expressed by cells of the megakaryocytic/platelet lineage,and is a member of the immunoglobulin gene superfamily,closely related to Fc receptor gamma chain (FcRgamma) and natural killer receptors.Glycoprotein VI plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation.This procoagulant function may contribute to arterial and venous thrombus formation.The signaling pathway involves the FcRgamma,the Src kinases (likely Fyn/Lyn),the adapter protein LAT and leads to the activation of phospholipase C gamma2.GPVI deficiency can result in bleeding disorders.Further study should reveal the extent of GPVI involvement in thrombotic disease and allow the development of alternative anti-thrombotic compounds. |
| Uniprot ID | Q9HCN6 |
| 基因名全称 | Glycoprotein VI (platelet) |
| 蛋白名全称 | Glycoprotein VI (platelet) |
| 推荐稀释比 | GPVI antibody can be used for detection of GPVI by Western blot at 1μg/mL.Antibody can also be used for immunohistochemistry starting at 10μg/mL.For immunofluorescence start at 20μg/mL.Antibody validated:Western Blot in mouse samples;Immunohistochemistry in human samples and Immunofluorescence in human samples.All other applications and species not yet tested. |
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